Objective of the study was to evaluate the sensitivity and specificity of tumor marker HE4 and ROMA tests in diagnosis ovarian cancer. Correlation tumor marker HE4 and ROMA tests with type and stage of malignancy. The results showed that the sensitivity of HE4 were 82.5 percent, the spescificity of HE4 were. 90 percent. The sensitivity of ROMA test is 95 percent, the spescificity of ROMA test is 44,3 percent. HE4 is highest in serous tumors, endometrioid tumors. In conclusions, HE4 is having high value in diagnosis ovarian cancer. ROMA test is having high sensitivity.