Objective: the authors studied Gonorrhea and Chlamydia in the female sex workers (FSWs) with and without sexually transmitted disease (STD) symptoms at Vocational Education Centers and Community Clinics in Ho Chi Minh city. Methods: A cross-sectional study was performed among 175 FSWs recruited in vocational education centers and community clinics in Ho Chi Minh city from 5/2008 to 5/2009. They were examined, interviewed and tested for HIV and other sexually transmittep infections (STls), (N. gonorrhoeae, C. trachomatis...). Results: 60 percent FSWs had STD symptoms and 40 percent FSWs without STD symptoms. The following characteristics (age, education, residential areas and marital status) of two FSWs groups were not statistically significant different (p 0.05). FSWs with STD symptoms had Chlamydia higher than FSWs without STD symptoms (20 percent vs 12.9 percent, P = 0.22). The rate of Gonorrhea and HIV in two groups were not different. FSWs with STD symptoms had risk cervicitis 2.2 times than those without STD symptoms, (p = 0.03). FSWs with cervicitis had risk Chlamydia infection 3.4 times than other FSWs, (p = 0.002). FSWs, who worked at many places and had unsafe sex were easy to get STDs. Conclusions: The rate of the two FSWs groups having STD symptoms or not having STD symptoms were not significant different. It showed that FSWs without STD symptoms might be a hidden source of infection for community.