Design and synthesis of novel thioether analogs as promising antiviral agents: In vitro activity against enteroviruses of interest.

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Tác giả: Hawa Sophia Bouzidi, Antonio Coluccia, Carole di Giorgio, Florence Gattacceca, Omar Khoumeri, Manon Roche, Hugo Roux, Pietro Scio, Romano Silvestri, Franck Touret, Patrice Vanelle

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: France : European journal of medicinal chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 559487

The Enterovirus genus contains two major subgroups: rhinovirus (RV) species A-C and enterovirus (EV) ones A-D. While RV only infects the respiratory system, the EV can cause a wide variety of diseases, ranging from non-specific febrile illness to severe neurologic complications. To date, no curative treatments are commercially available. Our research team had recently developed EV-A71 inhibitors. To improve their activity and broaden their spectrum, we performed optimization of the structure following an iterative cycle of chemical modulations. As a result, we obtained two broad-spectrum inhibitors with micromolar activity against these 3 types of viruses (OM1260: EC
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