Purpose: The aim of this study is to investigate the feasibility, safety and effectiveness of the laparoscopic surgery (LS) techniques in the management of congenital duodenal obstruction (CDO) in children. Methods: Medical records of patients with the diagnosis CDO undergoing LS at the center from March 2009 to July 2013 were reviewed. laparoscopic duodeno-duodenostomy was carried out using the technique of "simple" oblique anastomosis. Results: 42 patients with a median age at operation of 11 days and a median weight of 2650 g were identified. Type I atresia, type III atresia and annular pancreas were found in 27 (64.2 percent), 9 (21.4 percent) and 6 (14.3 percent) patients, respectively. Laparoscopic duodeno-duodenostomy was carried out in 39 patients, duodenotomy and web excision in 2, and jejuno-duodenostomy in 1 patient. There was no conversion to open surgery. The median time to initial postoperative oral feeding was 4.0 days. There was no anastomotic leak or stenosis. The median postoperative hospital stay was 7.0 days. Conclusions: LS is feasible, safe and effective for the treabnent of CDO in selected children at experienced centers. The technique of simple oblique anastomosis for laparoscopic duodeno-duodenostomy is a viable option in LS for CDO.