Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis.

• Tác giả: Jesus Alegre-Díaz, Jaime Berumen, Oliver S Burren, Keren Carss, Rory Collins, Sri V V Deevi, Ryan S Dhindsa, Jonathan Emberson, Margarete A Fabre, Andrew R Harper, Fengyuan Hu, Pablo Kuri-Morales, Douglas P Loesch, Jonathan Mitchell, Abhishek Nag, Slavé Petrovski, Katherine R Smith, Ioanna Tachmazidou, Haeyam Taiy, Roberto Tapia-Conyer, Jason M Torres, George S Vassiliou, Quanli Wang, Sebastian Wasilewski, Sean Wen
• Ngôn ngữ: eng
• Ký hiệu phân loại: 700.105 Effects of science and technology on the arts
• Thông tin xuất bản: United States : Nature genetics , 2025
• Bộ sưu tập: NCBI
• ID: 55968

Tóm tắt

The impact of genetic ancestry on the development of clonal hematopoiesis (CH) remains largely unexplored. Here, we compared CH in 136,401 participants from the Mexico City Prospective Study (MCPS) to 416,118 individuals from the UK Biobank (UKB) and observed CH to be significantly less common in MCPS compared to UKB (adjusted odds ratio = 0.59, 95% confidence interval (CI) = [0.57, 0.61], P = 7.31 × 10