Applicating the supraorbital minicraniotomy surgical approach for the anterior skull base brain tumors. Objective: The supraorbital minicraniotomy surgical approach (Key hole technique) for the anterior skull base fossa brain tumors (suprasellea meningioma, craniopharyngiomas, pituitary adenoma, subarachnoid cyst...). Material and method: Report on 34 patients with different lesions perfomed by this technque. A small incision (50mm) in the eyebrow and a supra orbital minicraniotomy are performed. Results: the intracranial hypertention symptoms, visual loss were the most common clinical symptoms with anterior skull base tumor. Microsurgery total removal of the tumor was 70,6 percent. The good outcome after tumor resection was 41,2 percent. Conclusion: The supraorbital minicraniotomy surgical approach associated with microsurgery was selected mini invasive technique, provides a good way approach to the anterior skull base brain tumors.