BACKGROUND: International collaborations have been pivotal in global health delivery, particularly in addressing challenges like tuberculosis. Recently, there has been a shift towards more focused alliances designed for targeted collaboration. This study examines health alliances as a distinct model of international partnership in global health, exploring their operational approaches, key activities, encountered challenges, and potential contributions. METHODS: A qualitative approach was utilised, in which ten semi-structured interviews were conducted with individuals involved in various health alliances. These were transcribed, anonymised, and analysed to identify common themes. RESULTS: Four main themes were generated, revealing that health alliances operate through collaborative efforts pooled from diverse stakeholders, including governments, and academic institutions. Serving as platforms for open communication, these alliances facilitate the exchange of expertise, resources, and best practices. The study highlights key activities undertaken by health alliances, including research, capacity building, policy engagement, and resource mobilisation. These activities strengthen health systems, generate new knowledge, and mobilise financial and technical resources. CONCLUSION: This research demonstrates the potential of health alliances as effective models for future collaborations in global health. By addressing the challenges of fragmentation, lack of coordination, and limited focus on capacity building and evaluation, health alliances enhance the impact of global health initiatives. The findings contribute to a better understanding of health alliances and could inform the development of future alliances.