Unveiling the role of chromosome structure morphology on gene function through chromosome conformation analysis.

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Tác giả: Frank Alber, Lorenzo Boninsegna, Asli Yildirim, Yuxiang Zhan

Ngôn ngữ: eng

Ký hiệu phân loại: 415.9 Morphology

Thông tin xuất bản: England : Genome biology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 56200

Single-cell chromosome conformations vary significantly among individual cells. We introduce a two-step dimensionality reduction method for density-based, unsupervised clustering of single-cell 3D chromosome structures from simulations or multiplexed 3D-FISH imaging. Our method clusters up to half of all structures into 5-12 prevalent conformational states per chromosome. These states are distinguished by subdivisions into chromosome territory domains, whose boundary locations influence subnuclear positions and speckle associations of certain genes and establish long-range structural variations of more than 10 Mb. Territory domain boundaries are found at few sequence locations, shared among cell types and often situated at syntenic breakpoints.
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