Synthesis and Bio-evaluation of Quaternized Fused-β-carbolines as anti-MRSA agents.

• Tác giả: Sanjay Batra, Sidharth Chopra, Rahul Maitra, Deepanshi Saxena, Adilakshmi Vutla
• Ngôn ngữ: eng
• Ký hiệu phân loại: 920.71 Men
• Thông tin xuất bản: Germany : ChemMedChem , 2025
• Bộ sưu tập: NCBI
• ID: 56301

Tóm tắt

The drastic increase in the emergence of methicillin and vancomycin resistant S. aureus has resulted in almost negligible treatment options available to tackle these drug-resistant strains and therefore, search for newer antibiotics is essential. In this context, a new series of quaternized fused β-carbolines was synthesized and evaluated for its anti-bacterial potential. Several compounds from the series displayed potent anti-bacterial activity against Gram-positive bacteria including the drug-resistant strains with minimal cytotoxicity and promising bactericidal action.