Studying 111 patients who had been mechanically ventilated and no previous evidence of pneumonia at ICU of No.103 Hospital from 1/2013 to 12/2013. The patients were divided in 2 group. The group 1: 55 patients were intubated with a endotracheal tube allowing drainage of subglottic secretions, and the group 2: 56 patients were Intubated with a conventional endotracheal tube as control group. Assessment of the effectiveness of endotracheal tube allowing the drainage of subglottic secretions in preventing ventilator-associated pneumonia and the influence of the endotracheal tube into the trachea injury. The results showed: Endotracheal tube allowing drainage of subglottic secretions is effective in preventing pneumonia, including early - onset and late - onset (incidence of VAP 25.45 percent, early-onset VAP 3.64 percent, late - onset VAP 21.81 percent compared with 48.21 percent, early-onset VAP 12,50 percent, late-onset VAP 35.71 percent in control group). The postextubatlon laryngeal dyspnea, reintubatlon were not significantly different between the two groups.