Objectives: To compare clinical and laboratory features of neonatal and post-neonatal congenital diaphragmatic hernia. Patients and methods: Retrospective study. Patients who received treatment of congenital diaphragmatic hernia at NHP from 2001 to 2012. Results: There were 438 patients included 246 neonates and 192 post-neonates. The rate of neonatal patients with congenital diaphragmatic hemia having postnatal respiratory failure was 93 percent, higher than postnatal patients with diaphragmatic hemia (24 percent). In neonatal patients with congenital diaphragmatic hernia X-rays showed blurred lung on the hernia side. In postnatal patients, X-rays showed blurred lungs on both two side. The rate of small bowel follow-through for neonatal patients revealing hernia stomach and bowel loops was 57.3 percent and 26,6 percent in postnatal patients. 45 percent of neonatal patients having congenital diaphragmatic hernia suffered from pulmonary arterial hypertension while the rate was 3 percent in postnatal patients. Conclusions: Respiratory failure and in pulmonary arterial hypertension are clear-cut symptoms in neonatal patients. Recurrent pulmonary infection most happens in postnatal congenital diaphragmatic hemia patients.