OBJECTIVES: To compare the mean deflection angles as well as the anterior and posterior lengths of the cranial base in different sagittal skeletal patterns. METHODS: The cross-sectional study was conducted at the Department of Orthodontics, Sharif Medical and Dental College, Jati Umrah, Lahore, Pakistan, from December 2022 to May 2023, and comprised orthodontic patients of either gender aged 8-20 years. Pre-treatment lateral cephalograms of the patients were traced on lead acetate tracing sheet with 0.03mm mechanical pencil. Outcome variables for the cranial base nasion-sella-articulare, nasionsella- basion, nasion-sella and sella-basion were recorded, and data was stratified for age and gender. Data was analysed using SPSS 23. RESULTS: Of the 93 patients, 60(64.5%) were females and 33(35.5%) were males. The overall mean age was 15.6±3.0 years, 38(40.9%) aged 8-14 years and 55(59.1%) aged 15-20 years. Mean values of cranial base flexion nasion-sellaarticulare, nasion-sella-basion and posterior cranial base length sella-basion were significant in different sagittal patterns (p<
0.05). Gender-based differences in mean values of anterior and posterior cranial base lengths were significant (p<
0.05). CONCLUSIONS: Cranial base flexion decreased significantly in skeletal class III. Cranial base lengths were higher for males than females, while age had no effect on cranial base morphology.