Precise staging of hepatic fibrosis is crucial for prognosis, surveillance and treatment decision in patients with chronic liver diseases in clinical practice. Liver biopsy has still the gold standard for assessment of hepatic fibrosis, but it has some limitations. To overcome this, noninvasive methods were developed assessing liver fibrosis including serum biomarkers and techniques measuring liver stiffness. However, each method has its own advantages and limits. Some studies suggest that the effectiveness of noninvasive methods for assessing liver fibrosis may increase when they are combined. The aim of this article is to report on thei different non invasive methods for assessment of hepatic fibrosis, their advantages and disadvantages, their diagnostic accuracy, their applications in clinical practice.