Purpose: To study the clinical features and etiology of lagophthalmos, to evaluate the relation between clinical feature and exposure keratitis. Methods: describe, cross design. A total 60 eyes of 60 patients with lagophthalmos treated in VNIO from 1/2012 to 6/2013. Results: The most common age group of lagophthalmos is from 20 to 40. The rate of male is higher than the rate offemale. Symptoms are: epiphora (65 percent) ,visual blurring (40 percent), pain (33.3 percent). 50 percent of patients had corneal exposure. 69 percent of patients had corneal diseases and in 22.4 percent corneal ulceration occurred All patient with paralytic lagophthalmos had a weakness of the orbicularis oculi muscle and decreasead rate of eye blinking, 72.7 percent a decreased corneal sensitivity, 63.6 percent a decreased tear secretion. The most common cause of paralytic lagophthalmos is traummatic paralysis (59.1 percent): temporal bone fracture, traumatic brain injury, after brain tumor surgery. Cicatricial lagophthalmos occurs after mechanical trauma (60.5 percent), chemical or thermal burns (23.7 percent), eyelid surgery (15.6 percent). Conclusion: clinical feature and etiology of lagophthalmos are very multiple and complex. Clinical feature and exposure keratitis have a strong relation.