Tổng hợp các bazơ mannich mới trên cơ sở acid ferulic

• Ngôn ngữ: vie
• Ký hiệu phân loại: 545.9 Quantitative analysis
• Thông tin xuất bản: Hóa học, 2014
• Mô tả vật lý: 206-210
• Bộ sưu tập: Báo, Tạp chí
• ID: 563508

Tóm tắt

The synthesis of novel Mannich bases based on Ferulic acid is described. Ferulic acid was first reacted with propargyl bromide and propargyl amine to give intermediates 2a and 2b, respectively. Next, the Mannich reaction of 2a and 2b with secondary amines in ethanol at reflux condition furnished two series of novel Mannich bases in good yields, 3a-h and 4a-h. All synthesized compounds were structurally characterized using spectroscopic methods NMR and MS.