The research describe knowledge, attitude towards HIV/AIDS prevention and to identify seceral risk factors related to HIV/AIDS prevention in residents at Hoa Thuong and Quang Son communes in Dong Hy district, Thai Nguyen province. An analytic, cross-sectional descriptive study was conducted on 400 people, aged 15-49, living in above communes. There were an association between level of education and understanding about HIV/AIDS as well as between educational level and attitude regarding HIV/AIDS.