Cross-sectional descriptive study on 250 primary caregivers (18 years old and older) of children under 5 years of age was conducted from 01/2013 6/2013 in Le Chi commune, Gia Lam district, Hanoi. The results showed that general knowledge about prevention of HFMD of caregivers wasn't high, the rate of knowledge was satisfactory 62.8 percent. Knowledge of the symptoms of HFMD were incomplete, only interested in the main symptoms of the disease. 8 percent caregivers didn't know about the risk of HFMD. The proportion of general satisfield practice on the prevention of HFMD was rather low (45.2 percent). Caregivers had good knowledge about disease prevention HFMD had good practice more than 5.8 times who .hadn't achieved knowledge. People should be regularly updated knowledge and practices on the prevention of HFMD.