Background: Traumatic brain injury causes lesions of primary and secondary, primary lesions leads to cerebral edema and consequently ultimately causing increased intracranial pressure. High value of intracranial pressure is the worse prognosis. Objectives: Valuation of intracranial pressure in patients with severe traumatic brain injury and find the correlation between intracranial pressure with Glasgow coma scale in patients with severe traumatic brain injury. Subjects and methods: 120 patients with severe traumatic brain injury treated at Hue Central Hospital, age or = 18. Results: 120 patients, 104 males, 16 females, 18-39 years old: 82 patients, 31 patients 40-60 years old, 60 years old: 7 patients. Group Glasgow score 3-6 points: 35 patients, Glasgow 7-8 points patients 85 patients. Intracranial pressure in patients with Glasgow 3-6 points: 32,78 + or - 9.63mmHg and intracranial pressure in patients with Glasgow 7-8 points: 30,06 + or - 9,25mmHg. Conclusion: In patients with severe traumatic brain injury, intracranial pressure increased and Glasgow coma scale decreased. While increasing intracranial pressure, the lower the Glasgow coma scale, worse prognosis.