Background: Brain injury causing inflammation immediately after the injury. The body responsed to this inflammation through neural hormon mechanisms. Another way, traumatic brain injury patients have elevated white blood cell count immediately. Subjects and methods: 120 patients with severe traumatic brain injury treated at Hue Central Hospital, age ~ 18. Results: 120 patients, 104 males, 16 females, 18-39 years old: 82 patients, 31 patients 40-60 years old, 60 years old: 7 patients. Group Glasgow 3-6 points: 35 patients, Glasgow 7-8 points: 85 patients. White blood cell at Glasgow group 3-6 points: (14.95 + or - 1.17)x103 and Glasgow group 7-8 points: (12.02 + or - 1. 95)x 103. Conclusion: In patients with traumatic brain injury, the higher of white blood cells is the low Glasgow Coma Scale. High value of white blood cells is the worse prognosis.