Vietnam has a high percentage of patients getting gastric ulcer, gastro esophageal reflux disorder. Some of them are terminally ill with possibility of producing side-effect such as serious ulcer, cancer of the oesophagus if they are not cured in time. Studies conducted from 2/2010 to 11/2010 with 115 patients by method of cross-sectional survey to learn about clinical features, ultrasonic images of histopathology of gastro esophageal reflux disorder. Information collection via questionnaires aims at evaluating degree of the symptoms. Results of those studies indicated that male patients were lower than female ones. Group of age who suffer such disease most is 31-40 years old. Incubation period lasts 1 week at least and no more than 12 months. It frequently recrudesces. Clinical symptoms include: 35.7 percent heartburn purely, 27 percent heartburn accompanied with other symptoms, (16.5 percent) hard-to-swallow, (13 percent) symptoms occurring outside the oesophagus (cough, hoarse...). Esophageal histopathology: chronic oesophagitis (21.4 percent), ulcer (42.9 percent), Barret (7.1 percent). Gastric histopathology: chronic gastritis (37.5 percent), ulcer (37.5 percent), atrophy (6.2 percent). The patients getting serious clinical symptoms have more severe trauma on oesophagus.