Death because of road traffic injury is the leading cause of death among young and adult population in the world. lt is estimated that there are over a million deaths and 50 million disabled due to road traffic injury. This study was carried out with 1050 driversto assess the knowledge, attitude and practice of the traffic safety in Hanoi, Bac Ninh, Quang Ninh, Vinh Phuc and Ho Chi Minh city. Results showed that 17.4 percent of people have had to drive after drinking 2 hours in the last 2 months. When asked about the main reasons for driving after drinking, 38.3 percent drivers answered that they wanted to go home, 14.8 percent had been driving after drinking alcohol with the reason that their home was close. Two consequences that most study subjects said that drinking alcohol can cause traffic accidents and reduce alertness while driving. Only 30.7 percent of drivers had correct answer on the legal level of alcohol while driving. The ability to be penaltied while drinking and driving while drinking and driving, the study subjects are assessed at a lower level. Main recommendations of the study is the need to have long-term intervention strategy to raising awareness and changing behavior of people related to drink and driving.