From the methanol extract of Vietnamese marine sponge Amorphinopsis excavans, five known compounds, 24-methylcholestane-3beta,5alpha,6beta,25-tetrol 25-monoacetate (1), 24-methylcholestane-lbeta,3beta,5alpha,6beta,25-pentol 25-monoacetate (2), (2S)-1-O-(2',3',4',5'-tetrahydroxycyclopentyl)-3-0-(10"-methylhexadecyl)glycerol (3), thymine (4), and cholesterol (5) were isolated. Their structures were identified by various spectroscopic methods in comparison with the literature values. Compounds 1 and 2 were isolated from soft corals but from this genus for the first time.