Background: For the treatment of end-stage chronic renal failure, renal .transplantation is considered the most effective method, not replace the function of excretion, but also recovery of cardiovascular changes. Echocardiography confirmed the superiority: a non-invasive, reproducible, inexpensive, help assess the changes of cardiac structure and function. The purpose of this study was to estimate left ventricular systolic function and morphology by echocardiography before and the first six months after kidney transplantation. Subjects and Methods: The end-stage renal disease patients underwent renal transplantation at Cho Ray hospital between Jan 2012 and July 2013. Echocardiographies were practiced before and 6 months after transplantation. Results: the authors assessed 57 patients (73.7 percent male, mean age 32.4 + or - 8.8). Echocardiographic results showed significant decreases in IVSd (13.5 + or - 2.2 vs 11.1 + or - 2.3mm, p0.001), LVPWd (13.1 + or - .2.1 vs 10.8 + or - 1.9mm, p0.001), LVDd (53.8 + or - 4.7 vs 47.0 + or - 4.9mm, p0.001), LVM (336.2 + or - 86.3 vs 212,4 + or - 45,2g, p0.001), LVMI (193.5 + or - 51.8 vs 137.4 + or - 27.6 g/m, p 0.001). Pretransplant LVH 97.4 percent, severe LVH significantly decreased (57.9 percent vs 15.8 percent, p0.001), MR (56.1 percent vs 10.5 percent, p0.001), E/A 1 ratio of MV pulsed Doppler (35.1 percent vs 15.8 percent. p0.001). There were significant increase in FS (33.3 + or - 4.8 percent vs 39.7 + or - 4.2 percent, p0.001), EF (61.4 + or - 7.2 percent vs 70.8 + or - 5.6 percent, p0.001). All of pre transplant low EF cases (EF55 percent) become normal (ER or = 55 percent, p0.05) after transplant. Conclusions: Successful renal trasplantation improves left ventricular morphology and function.