Electrochemical Aminooxygenation of Enamides.

• Tác giả: Chunyan Bai, Xiazhen Bao, Congde Huo, Dongsheng Ji, Hangfei Jiang, Xincong Liu, Yong Yuan, Feng Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 959.3031 *Thailand
• Thông tin xuất bản: United States : Organic letters , 2025
• Bộ sưu tập: NCBI
• ID: 56497

Tóm tắt

Herein, we present an unprecedented electrochemical approach for aminooxygenation of enamides with azoles under transition-metal- and oxidizing-reagent-free conditions. This method affords 4-azolated oxazolines directly from readily available starting materials in up to 95% yield. Central to our success is the utilization of electrical energy as the primary driving force and NaBr as a mediator. Importantly, the resulting 4-azolated oxazolines exhibit potential utility as ligands (pyrazole-oxazoline ligands) in transition-metal-catalyzed reactions.