Design, synthesis, and biological evaluation of oxime ether derivatives containing 1,5-dimethyl-6-thioxo-1,3,5-triazinane-2,4-dione as protoporphyrinogen IX oxidase inhibitors.

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Tác giả: Lianyang Bai, Zhendong Bai, Hao Li, Zuren Li, Dingfeng Luo, Changsheng Ma, Yuanhui Wan, Yingying Wang, Sheng Yan

Ngôn ngữ: eng

Ký hiệu phân loại: 967.61044 *Uganda and Kenya

Thông tin xuất bản: England : Pest management science , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 56506

 BACKGROUND: Herbicides based on protoporphyrinogen IX oxidase (PPO
  EC 1.3.3.4) are widely used for weeding control in agricultural fields to safeguard food security. PPO herbicides, because of their low dosage, rapid action on weeds, slow accumulation in the environment and low toxicity to mammals, have become an important field of research in the development of new herbicides. This study presents a novel molecular scaffold with remarkably potent herbicidal activity. RESULTS: A series of novel oxime ether derivatives containing 1,5-dimethyl-6-thioxo-1,3,5-triazinane-2,4-dione 6a-6z were designed and synthesized based on bioisosterism and substructure splicing, and characterized by CONCLUSION: Through bioisosterism and substructure splicing, we successfully developed compound 6r as lead compound exhibiting herbicidal activity, with no harm to rice and honeybees. Further development of herbicides based on this scaffold is warranted. © 2025 Society of Chemical Industry.
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