OBJECTIVE: This report describes the implementation and evaluation of a unique escape room game/unfolding public health preparedness simulation into nursing education. The innovative approach was designed to teach disease investigation, epidemiological principles, and technical skills such as the tuberculosis (TB) skin testing techniques. METHODS: The escape room/unfolding health preparedness simulation was implemented with 29 pre-licensure nursing students and involved game-like activities as well as a realistic disaster simulation scenario with standardized patients. RESULTS: The project yielded positive outcomes, with students demonstrating increased knowledge and confidence. Students also recommended the simulation for teaching disaster preparedness, highlighting its effectiveness. Evaluation data also suggested refinement of the simulation around the nurses' roles. CONCLUSIONS: While implementing this teaching innovation had challenges, the approach enhanced active learning, critical thinking, and teamwork in nursing education, preparing students for real-world health care challenges. The project underscores the importance of such simulations in training nursing students for public health emergencies. It also highlights the need for further research to assess long-term impacts on student outcomes, indicating the potential for continued improvement and development in the field.