Protein condensates as membrane-less compartments play a pivotal role in cellular processes. The stabilization of protein condensation can be tuned using cosolutes which directly impact biological function. In this study, we report the result of a rigorous study of the influence of cosolutes changes on hydration entropy and enthalpy upon condensate formation, by means of THz-calorimetry. Our results unveil quantitative insights into the fine tuning of the free energy imbalance,