Unveiling a novel RNA G-triplex structure: its function and potential in CRISPR-based diagnostics.

• Tác giả: Xiaoling He, Runchen Li, Tao Li, Ying Li, Zheyu Li, Zhihao Li, Mengjun Wang, Yunhuang Yang, Guojun Zhang, Yuanqing Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Chemical communications (Cambridge, England) , 2025
• Bộ sưu tập: NCBI
• ID: 56605

Tóm tắt

We report the discovery of a novel higher-order RNA structure, RNA G-triplex (rG3), formed by the TERRA sequence. Through CD spectroscopy, NMR analysis, and molecular modeling, we confirmed its stable, parallel conformation. rG3 exhibits strong binding to thioflavin T (ThT),