Tuong Duong is a high moutainous district that is located in the West of Nghe An province ana far away from Vinh city about 180 km, over 90.6 percent of population is ethnic minorities and the key production is agriculture. In the past years, there have many programs and projects of agriculture development and poverty reduction have been invested in the district region and achieved the significant results, contributed to food security, improved the physical and spiritual life for villagers. However, besides these achievements, .the agriculture sector of Tuong Duong district has still had the shortcomings and challenges, the agriculture development is still unstable, it does not ensure the harmonization and linkage of economic, social and environmental benefits. Therefore, the paper is focused to analyze and research on the real situation of the district's agriculture development, find out its effected factors, identify difficulties, strengths, weakness, oppotunities and threats and recommend the main solutions to agriculture development in the sustainable direction. The research uses the descriptive statistic methodology and comparative statistic methodology at the aim to express the nature of research objects through expression of the theories and practices of sustainable agriculture development, synthesis and comparison of data in the research process.