This paper examines the determinants of entrepreneurial interest among senior students at Thai Nguyen University of Economics and Business Administration in Vietnam based on sample survey conducted in 2012. Although there have been past studies related to entrepreneurial interest of students, this study is one of the first comprehensive studies of the attitudes of undergraduates toward entrepreneurship in Vietnam. Four background factors (gender, major, average grade and family experience with business) and four attitude determinants (interests, confidence, willingness and economic aspirations) were found to affect TUEBA senior students' entrepreneurial propensity. Among the significant factors identified, that pertaining to inadequate business knowledge had direct policy implications for university administrators, as it strongly suggests the need to provide students with comprehensive and intensive programs that impart business knowledge. Furthermore, the government can also contribute by promoting more awareness of successful entrepreneurial role models, removing bureaucratic impediments to start-up, and avoiding the social stigma of failure.