Purpose Chronic otitis media (COM) is generally characterized by tympanic membrane perforations. A vast range of antimicrobial as well as surgical procedures is done for the management of COM. This study aimed to assess the outcome of bilateral endoscopic tympanoplasty with that of conventional microscopic tympanoplasty. Materials and methods This is an interventional-prospective, comparative study. The study took place for one year, i.e., from September 2022 to August 2023. It was performed at the Department of Otorhinolaryngology, Sharda Hospital, School of Medical Sciences and Research, Sharda University (Greater Noida, UP, IND). The study included 66 participants who were divided into two groups, namely the bilateral endoscopic tympanoplasty group and the conventional microscopic tympanoplasty group. Ethical clearance was obtained before the initiation of the study. Results In this study, BMI was significant between bilateral endoscopic tympanoplasty and conventional microscopic tympanoplasty groups with a p-value of 0.03. The graft uptake rate postoperatively was found to be similar at 32 (97%) in the bilateral endoscopic tympanoplasty and 31 (94%) in the conventional microscopic tympanoplasty group. Air-bone gaps were decreased after surgery during follow-up months in the order of after 1 month, three months, and six months. Hearing was automatically improved after surgery, and the rate of improvement among the participants of both groups was similar. Conclusion The bilateral endoscopic and conventional microscopic tympanoplasty groups did not differ significantly from one another. Air-bone gaps were decreased in the duration of the follow-up period and were similar in both groups. However, it seemed easier to perform bilateral endoscopic tympanoplasty in a shorter time. Thus, bilateral endoscopy may have advancements over the conventional method.