The consumption of healthy food has become increasingly present and eating fresh, quality fruit is part of this trend. Nevertheless, the scarcity of fresh water and the increasing demand for food have been driving the search for more sustainable agricultural practices worldwide. In this context, cultivation with lower-quality water, characterized by a high concentration of salts, emerges as alternative to enhance water use efficiency and ensure food security in regions prone to water scarcity. In this regard, the aim of this work was to use an NMR-based metabolomics approach to investigate the growth and metabolomic profile of yellow melon fruits and leaf cultivated under water salinity conditions (1.5, 2.5, and 4.5 dS m