OBJECTIVE: Ischemic stroke (IS) is a major public health concern worldwide. In this study, we aimed to investigate the relationship between METHODS: We performed a comprehensive search of the PubMed, China National Knowledge Infrastructure, Web of Science, and WANFANG databases for articles published until February 2024. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the association between RESULTS: Eleven studies containing 2,228 cases and 2,556 controls met the inclusion criteria. Our results showed that aspirin resistance in patients with IS was significantly correlated with the polymorphism of CONCLUSION: This meta-analysis suggests a potential link between