Objective: To determine the antibiotic resistance percentage of causative agents of ventilator associated pneumonia (VAP) in patients with stroke receiving intubation and ventilator. Subject and methods: 45 bacteria isolated from 50 patients with VAP in the ICU of friendship hospital. A descriptive study: Sensitivity testing was performed by disk diffusion method Stroke patients who were admitted to Intensive Care Unit (ICU) with over 48 hours of mechanical ventilation, diagnosed ventilator associated pneumonia. Eligible patients were conducted endoscopy, bronchoalveolar lavage taken for microbial culture and antibiotic sensitivity testing. Results: The rate of gram - negative bacteria was 90 percent. Among of them, 28 percent E. coli, 16 percent P. aeruginosa, 12 percent Burkhoderia, 10 percent A. baumannii and Klebsiella. Gram - positive Coryneb.acterium was 8 percent and S. viridans was 2 percent. The gram - negative bacteria showed 90 percent resistance to most of antibiotics in Cephalosporins, Aminoglycosids and Quinolons group. Conclusions: The most common agent causing ventilator associated pneumonia is gram - negative bacteria with the high rate of antibiotic resistance, over 90 percent to almost antibiotics Cephalosporins, Quinolons and Aminoglycosids.