INTRODUCTION: Methicillin-resistant METHODS: A polymerase chain reaction (PCR) assay was developed to detect the presence of the RESULTS: A total of 26 STs were identified, with notable prevalence in five epidemic clones: ST59, ST5, and ST764. The prevalence of the DISCUSSION: Notably, forty-seven (61%) MRSA BSI strains were multidrug-resistant, with the majority exhibiting resistance to penicillin, erythromycin, and clindamycin. Major MRSA clones in southern China include ST59, ST5, ST764, and ST398. In this study,