MRI-derived radiomics models for prediction of Ki-67 index status in meningioma: a systematic review and meta-analysis.

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Tác giả: Mahshad Afsharzadeh, Nima Broomand Lomer, Delaram J Ghadimi, Hamed Ghorani, Fattaneh Khalaj, Mohammad Mohammadi, Houman Sotoudeh, Sina Zakavi

Ngôn ngữ: eng

Ký hiệu phân loại: 519.287 Expectation and prediction

Thông tin xuất bản: United States : Clinical imaging , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 569868

PURPOSE: The Ki-67 marker reflects tumor proliferation and correlates with meningioma prognosis. Here we aim to evaluate the performance of MRI-derived radiomics for Ki-67 index prediction in meningiomas. METHODS: After a comprehensive search in Web of Science, PubMed, Embase, and Scopus, data extraction and risk of bias assessment was performed. Pooled sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), and diagnostic odds ratio (DOR) were computed. The summary receiver operating characteristic (sROC) curve was generated and area under the curve (AUC) was calculated. Separate meta-analyses were conducted for radiomics models and combined models. Heterogeneity was evaluated using the I RESULTS: Seven studies were included, with six studies analyzed for radiomics model and four for combined model. For radiomics model, the pooled sensitivity, specificity, PLR, NLR, DOR, and AUC were 67 %, 82 %, 8.61, 3.54, 0.43, and 0.79, respectively. For combined model, pooled sensitivity, specificity, PLR, NLR, DOR, and AUC were 78 %, 78 %, 12.19, 3.47, 0.30, and 0.79, respectively. Sensitivity analysis identified no outliers. In radiomics model, potential sources of heterogeneity included mean age and the application of N4ITK bias correction. For combined model, heterogeneity was influenced by mean age, application of N4ITK bias correction, and the use of external validation. CONCLUSION: Radiomics shows promising ability to predict the Ki-67 index status in meningioma patients, potentially enhancing clinical decision-making and management strategies.
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