Boiling histotripsy (BH) has proven effective in noninvasively disintegrating various soft tissues through cavitation effects. Although liquefied tissue appears as hypoechoic in sonography, the transition of BH-induced bubbles from hyperechoic to hypoechoic in the focal region typically requires several minutes. To facilitate rapid clinical assessment, a tandem pulse sequence of high-power BH pulses (with an acoustic power of 1484 W, a pulse duration of 10 ms, and a pulse repetition frequency of 1 Hz) followed by low-power long ultrasound pulses (with an acoustic power of 240 W, a pulse duration of 100 ms, and a pulse repetition frequency of 1 Hz) was introduced to expedite bubble clearance, resulting in an immediate hypoechoic presentation in sonography. This method was evaluated through high-speed photography, red blood cell (RBC) phantom, and ex vivo tissue experiments. High-speed photography experiments captured the enhanced bubble clearance induced by the low-power long pulses, validating our hypothesis. In RBC phantom experiments, conventional BH sequences yielded hypoechic patterns after 4.39 ± 0.84 min, whereas the tandem pulse sequences achieved hypoechic appearance instantaneously post-treatment (p <
0.05). Moreover, the tandem pulse sequences increased the erosion area in the RBC layer by 7.8 folds, from 2.36 ± 0.88 mm