Case report: Complete response of recurrent locally advanced basal cell carcinoma following addition of vismodegib to neoadjuvant cemiplimab therapy.

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Amin Hedayat, Chalette Lambert-Swainston, Brandon Reynolds, Wolfram Samlowski

Ngôn ngữ: eng

Ký hiệu phân loại: 627.12015325 Inland waterways

Thông tin xuất bản: Switzerland : Frontiers in oncology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 57013

Thêm vào giỏ Liên kết toàn văn

Locally advanced basal cell carcinoma (laBCC) remains a significant management challenge. Historically, surgery or radiotherapy represented the major treatment options. Recently, hedgehog inhibitors and checkpoint inhibitors have demonstrated significant activity. The optimal sequencing of these approaches is not yet known. We describe a case of laBCC that recurred after definitive radiotherapy. This patient was treated with neoadjuvant cemiplimab with minimal response. Cautious addition of vismodegib with ongoing cemiplimab treatment was well tolerated and resulted in significant tumor regression. A wide excision demonstrated a pathologic complete response. Further evaluation of cemiplimab and hedgehog inhibitor combination therapy in la BCC appears warranted.

Tạo bộ sưu tập với mã QR