Restoration of Type 17 immune signaling is not sufficient for protection during influenza-associated pulmonary aspergillosis.

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Tác giả: Aijaz Ahmad, Kwame Frempong-Manso, Caden Ngeow, Kara L Nickolich, Matthew J Pilewski, Keven M Robinson, Ravineel B Singh

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Switzerland : Frontiers in immunology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 57038

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INTRODUCTION: Influenza-associated pulmonary aspergillosis (IAPA) is a severe complication of influenza infection that occurs in critically ill patients and results in higher mortality compared to influenza infection alone. Interleukin-17 (IL-17) and the Type 17 immune signaling pathway cytokine family are recognized for their pivotal role in fostering protective immunity against various pathogens. In this study, we investigate the role of IL-17 and Type 17 immune signaling components during IAPA. METHODS: Wild-type mice were challenged with influenza A H1N1 (flu) and then exposed to RESULTS AND DISCUSSION: The gene and protein expression levels revealed that IL-17 and Type 17 immune cytokines and antimicrobial peptides are downregulated during IAPA compared to mice singularly infected solely with

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