Qishen Granule protects against myocardial ischemia by promoting angiogenesis through BMP2-Dll4-Notch1 pathway.

• Tác giả: Xu Chen, Dongqing Guo, Yiqin Hong, Linghui Lu, Binghua Tang, Hui Wang, Qiyan Wang, Hanyan Xie, Lishuang Yu, Jingmei Zhang, Yawen Zhang, Xinyi Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 070.48346 Journalism
• Thông tin xuất bản: Singapore : Chinese herbal medicines , 2025
• Bộ sưu tập: NCBI
• ID: 57063

Tóm tắt

OBJECTIVE: Therapeutic angiogenesis has become a promising approach for treating ischemic heart disease (IHD). The present study aims to investigate the effects of Qishen Granule (QSG) on angiogenesis in myocardial ischemia (MI) and the potential mechanism. RESULTS: The results showed that QSG improved heart function, cardiac blood flow and microvessel density in myocardial ischemic rats. CONCLUSION: QSG protected against MI by promoting angiogenesis through BMP2-Dll4-Notch1 pathway. BMP2 might be a promising therapeutic target for IHD.