In the process of living and production, Thai ethnic in Northern mountain region has created a lot of experience in production and achieve success in many diffenrent sectors. The most important feature in the culturan behavior with the natural environment of the Thai ethnic is always difficul to overcome, flexible and ecological environment, Thai ethnic has accumulatsd a huge amount of folk knowledge of the living conditions in the mountains. The paper focuses to learn about indigenous knowledge in choosing the locality of residence and agricultural production characteristics of the Thai ethnic in the Northwest Vietnam.