Solidified reverse micellar solution-based chitosan-coated solid lipid nanoparticles as a new approach to enhance oral delivery of artemether in malaria treatment.

• Tác giả: Chinazom Precious Agbo, Paul Achile Akpa, Anthony Amaechi Attama, Adaeze Chidiebere Echezona, Reuben Ejike Eze, Thaddeus Harrison Gugu, Franklin Chimaobi Kenechukwu, Mumuni Audu Momoh, Chinekwu Sherridan Nwagwu, Chibuzor Stanley Offorbuike, Enyi Moses Ojukwu, Anthony Ikechukwu Onah, Emmanuel Chekwube Ossai, Teerapol Srichana, Chimaobi Odinaka Ugorji, Onyinyechi Lydia Ugorji, Calister Elochukwu Ugwu, Kingsley Chinazam Ugwu, Wilfred Ikechukwu Ugwuoke, Samuel WisdomofGod Uzondu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 636.08844 Animal husbandry
• Thông tin xuất bản: Switzerland : BMC chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 57075

Tóm tắt

Solidified reverse micellar technology and surface-modification are promising techniques for improving the biopharmaceutical properties of poorly water-soluble drugs such as artemether, a first-line antimalarial drug. Thus, the aim of this study was to develop and evaluate artemether-loaded chitosan-coated solid lipid nanoparticles (SLNs) based on solidified reverse micellar solution (SRMS) for improved oral malaria therapy. Artemether-loaded and unloaded SLNs were prepared from optimized SRMS (consisting of Phospholipon