Identification of sinensetin as a selective inhibitor for mitogen-activated protein kinase kinase 6 and an anticancer agent for non-small cell lung cancer.

• Tác giả: Dong Joon Kim, Tae-Sung Kim, Yeon-Sun Seong, Young Ran Shin, Xiaomeng Xie, Yong Weon Yi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 340.115 Law and society
• Thông tin xuất bản: United States : American journal of cancer research , 2025
• Bộ sưu tập: NCBI
• ID: 57185

Tóm tắt

Natural compounds are an invaluable source for bioactive small molecules. Cellular activities modulated by them are generally achieved by binding specific cellular targets. However, identification of target(s) for a natural compound is challenging and a hurdle for further development of them as drugs. Sinensetin is derived from