Adenylate cyclase 10 promotes brown adipose tissue thermogenesis.

• Tác giả: Vasileia Ismini Alexaki, Triantafyllos Chavakis, Anupam Das, Andreas Deussen, Ruben Garcia-Martin, Eman Hagag, Eleftheria Karadima, Christine Mund, Thomas Noll, Mirko Peitzsch, Anke Witt
• Ngôn ngữ: eng
• Ký hiệu phân loại: 571.538 *Tissue culture
• Thông tin xuất bản: United States : iScience , 2025
• Bộ sưu tập: NCBI
• ID: 57212

Tóm tắt

Brown adipose tissue (BAT) thermogenesis dissipates energy through heat production and thereby it opposes metabolic disease. It is mediated by mitochondrial membrane uncoupling, yet the mechanisms sustaining the mitochondrial membrane potential (ΔΨm) in brown adipocytes are poorly understood. Here we show that isocitrate dehydrogenase (IDH) activity and the expression of the soluble adenylate cyclase 10 (ADCY10), a CO