Endothelial monocarboxylate transporter 1 drives atherosclerosis via a lactate/NADH/CtBP-mediated transrepression pathway.

• Tác giả: Zaixia Bai, Kaixiang Cao, Yixin Chen, Yuxi Duan, Shuai Guo, Jun He, Wenzhong Hou, Shuqi Huang, Ziling Li, Zou Li, Mingchuan Song, Cailing Wang, Yiming Xu, Bin Yang, Runfa Yu, Shihui Yu, Yuting Zhang, Yuan Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 011.7 *General bibliographies of works having specific kinds of content
• Thông tin xuất bản: China : MedComm , 2025
• Bộ sưu tập: NCBI
• ID: 57217

Tóm tắt

The accumulation of lactate in tissue microenvironments is associated with atherosclerosis, but its precise role in atherogenesis remains largely unknown. This study demonstrated that lactate accumulation in aortic tissues and blood is correlated with increased monocarboxylate transporter 1 (Mct1) expression in endothelial cells (ECs) within atherosclerotic plaques. Lactate uptake via Mct1 triggers an inflammatory response in ECs. The administration of endothelial-targeting nanoparticles containing siRNA against