Development of a multi-year pediatric antibiogram in Georgia identifies antibiotic resistance changes over the past ten years.

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Tác giả: Madeleine Goldstein, Mark D Gonzalez, Tracy Huang, Robert C Jerris, Matthew Linam, Adrianna Westbrook

Ngôn ngữ: eng

Ký hiệu phân loại: 571.876 +Development in distinct stages

Thông tin xuất bản: England : Antimicrobial stewardship & healthcare epidemiology : ASHE , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 57269

BACKGROUND: Antibiograms monitor antibiotic resistance trends and help guide empiric antibiotic treatment. A statewide pediatric antibiogram can help inform stewardship efforts. METHODS: Annual pediatric antibiograms for the five children's hospitals in Georgia from 2014-2023 were collected. All sites used the Clinical and Laboratory Standards Institute guidelines for antibiogram development. Antibiogram data were combined, and the most common bacteria were included: Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex and Pseudomonas aeruginosa. Interhospital differences were compared for methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), E. coli and K. pneumoniae. The combined data from 2014 and 2023 were compared to demonstrate antibiotic susceptibility changes over time. RESULTS: Data in 2023 for MSSA and MRSA showed clindamycin susceptibility was 78% and 82%, respectively. S. pneumoniae susceptibility to amoxicillin/clavulanate was 96%. E. faecalis resistance to ampicillin and vancomycin was rare. For all included gram-negative bacteria, susceptibility remained high to 3 CONCLUSION: Over the past 10 years, MRSA rates decreased, S. pneumoniae antibiotic susceptibility increased, and gram-negative bacilli susceptibility was stable to slightly decreased. Georgia antibiogram data support the recommended antibiotic treatment for common pediatric infections.
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