Markov Models and Long-term Memory in Ion Channels: a Contradiction in Terms?

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Tác giả: Vincenzo Carnevale, Daniel Sigg

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Biophysical journal , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 57272

The opening kinetics of an ion channel are typically modeled using Markov schemes, which assume a finite number of states linked by time-independent rate constants. Although aggregate closed or open states may, under the right conditions, experience short-term (exponential) memory of previous gating events, there is experimental evidence for stretched-exponential or power-law memory decay that does not conform to Markov theory. Here, using Monte Carlo simulations of a lattice system, we investigate long-term memory in channels coupled to a heterogeneous membrane near the critical temperature. We observed that increasing the strength of the channel-lipid coupling parameter from zero to nearly 1 kT per lipid binding site leads to a progression in the autocorrelation of successive open dwell times. This evolution changes from (i) multiexponential decay to (ii) power-law decay, and finally to (iii) stretched exponential decay, mirroring changes in channel distribution from: (i) complete independence, (ii) partitioning in the interphase between lipid domains, and (iii) partitioning inside the domain favorable to the activation state of the channel. The intermediate power-law regime demonstrates characteristics of long-term memory, such as trend-reinforcing values of the Hurst exponent. Still, this regime passes a previously proposed Markovianity test utilizing conditional dwell time histograms. We conclude that low-energy state-dependent interactions between ion channels and a dynamic membrane soften the Markov assumption by maintaining a fluctuating microenvironment and storing configurational memory, supporting the existence of long memory tails without necessarily diminishing the usefulness of Markov modeling.
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