OBJECTIVES: Exclusive breastfeeding is a critical public health strategy known to reduce infant mortality and morbidity, and to enhance maternal and child health outcomes. This study explores the psychosocial factors affecting exclusive breastfeeding (EBF) among first-time mothers in Ghana, highlighting the challenges faced by first-time mothers in maintaining EBF for the recommended 6 months. METHODS: The study utilized an exploratory qualitative research design to gain in-depth understanding of first-time mothers' experiences with EBF, utilizing semi-structured interviews at the Salaga Municipal Hospital postnatal clinic. RESULTS: The study found stressors affecting mothers' exclusive breastfeeding practices, including lactation issues, infant positioning issues, and physical discomfort. Strong family support was found to be crucial for encouraging and sustaining EBF practices. CONCLUSION: Psychosocial factors significantly influence exclusive breastfeeding among first-time mothers. Strategies include addressing lactation issues, providing infant positioning education, alleviating physical discomfort, and enhancing family support systems.