Effect of Myelopeptide MP5 on Synaptic Plasticity of the Hippocampus during Addictive Memory Extinction in C57BL/6 Mice.

• Tác giả: N A Beregovoy, M V Starostina, G K Volcho
• Ngôn ngữ: eng
• Ký hiệu phân loại: 531.385 Plasticity
• Thông tin xuất bản: United States : Bulletin of experimental biology and medicine , 2025
• Bộ sưu tập: NCBI
• ID: 57638

Tóm tắt

The rapid formation and high stability of addictive memory are the main causes of frequent relapse of alcohol and drug diseases, which limits the possibility of complete recovery and necessitates the search for ways to disrupt the formation or enhance the extinction of addictive memory. The present work shows that myelopeptide MP5 accelerates the extinction of morphine-induced conditioned place preference in C57BL/6 mice and supports synaptic plasticity in the hippocampus, while MP2 produced no such effects.