The effect of vitamin D supplementation on endothelial function: An umbrella review of interventional meta-analyses.

• Tác giả: Dandan Chen, Yirui Chen, Liqun Hua, Ye Peng, Fangfang Shi, Manling Wang, Wensong Wang, Yanzhong Wang
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Nutrition, metabolism, and cardiovascular diseases : NMCD , 2025
• Bộ sưu tập: NCBI
• ID: 576507

Tóm tắt

 AIMS: There is no consensus in the existing literature regarding the effect of vitamin D supplementation on endothelial function. This umbrella review aimed to assess meta-analyses of randomized controlled trials (RCTs) conducted in this field. DATA SYNTHESIS: We systematically searched English-language databases, including PubMed, Embase, Scopus, and Web of Science, up to January 2024. Flow-Mediated Dilation (FMD), Pulse Wave Velocity (PWV), and Augmentation Index (AIx) were the primary endpoints evaluated. A total of 16 meta-analyses were included in the review. The results indicated that vitamin D supplementation significantly improved FMD as assessed by Standardized Mean Difference (SMD) (SMD = 0.72, 95 % CI: 0.34, 1.11
  p <
  0.001
  I CONCLUSION: These findings suggest that vitamin D supplementation may be a beneficial intervention for improving endothelial function, particularly in populations with low FMD. The effects on PWV were modest, while AIx remained unaffected. REGISTRATION NUMBER: PROSPERO, CRD42024451215.